oxaliplatincisplatin

一、研究背景Cisplatin（順鉑）是一個重要的抗癌藥物，具有嚴重的耳毒性，相對於cisplatin，oxaliplatin（草酸鉑）也屬於此類鉑金類抗癌藥物，卻具有不同的藥理特性.

由 T Chinen 著作 · 2022 · 被引用 3 次 — Conclusion. The oxaliplatin-based regimen may have comparable survival benefits with the cisplatin-based regimen among elderly patients with ...

由 F Montagnani 著作 · 2011 · 被引用 172 次 — In conclusion, the present analysis has confirmed that oxaliplatin is significantly less toxic than cisplatin, with the exception of diarrhea, ...

由 F Montagnani 著作 · 2011 · 被引用 172 次 — Oxaliplatin has been shown to be at least as effective as cisplatin for this disease, but with less toxicity and a better tolerability profile, especially for ...

由 AS Guerrero 著作 · 2023 · 被引用 2 次 — Herein, we report novel click-capable azide-modified oxaliplatin mimics that cause nucleolar stress. Through NPM1 relocalization, fibrillarin redistribution, ...

2020年8月12日 — Cisplatin induces more DNA damage than carboplatin or oxaliplatin. The different mutagenicity of the platinum drugs could be due to differences ...

This chapter begins with a brief historical review detailing initial results that led to the worldwide clinical approval of cisplatin and development of the ...

由 RK Mehmood 著作 · 2014 · 被引用 117 次 — Both cisplatin and oxaliplatin are DNA alkylating agents forming platinated intra-strand and inter-strand cross-links. Intra strand links ...

由 O Rixe 著作 · 1996 · 被引用 848 次 — Oxaliplatin has a different spectrum of activity and low cross-resistance to cisplatin and should be valuable in cisplatin refractory patients or in combination ...

由 J Lokich 著作 · 2001 · 被引用 82 次 — Oxaliplatin is a platinum analogue that is distinctive from both cisplatin ... oxaliplatin, may mitigate some of the toxicities observed with oxaliplatin.